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Home / US Department of Health and Human Services / PAR-25-446

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

Open now · Cooperative Agreement · PAR-25-446

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Next cut-off
21 Aug '28
in 715 days
Per grant
$3.0M
the call's own average
Grants expected
,
not published for this call
Funding rate
,
not published, read the conditions

In context of US Department of Health and Human Services

This grant$3.0M
The track runs to the largest grant in US Department of Health and Human Services ($42M). The median across the 961 calls we publish is $749K, this one is above it.

What this call funds

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

What applying costs you

ItemEstimateNote
Drafting effort3–4 weekssingle submission
Time to first payment6–9 monthscut-off → evaluation → grant agreement

These are Bemzu's estimates from the call's structure (the number of stages and whether a consortium is required) not figures published by the Commission. Only the co-financing share is read from the call itself.

Also open in HHS

CallNext cut-offPer grant
Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)PAR-25-038 · US Department of Health and Human Services · single applicant* 07 Sept '26in 1d , not published Alcohol Treatment, Pharmacotherapy, and Recovery Research (R34 Clinical Trial required)PAR-25-193 · US Department of Health and Human Services · single applicant* 07 Sept '26in 1d , not published Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)PAR-25-066 · US Department of Health and Human Services · single applicant* 07 Sept '26in 1d , not published Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21 Clinical Trial Optional)PAR-25-064 · US Department of Health and Human Services · single applicant* 07 Sept '26in 1d , not published Schizophrenia and related disorders during mid- to late-life (R01 Clinical Trial Optional)PAR-25-039 · US Department of Health and Human Services · single applicant* 07 Sept '26in 1d , not published

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